Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line

Drug resistance limits the efficacy of chemotherapy and targeted cancer treatments, calling for the identification of druggable targets to overcome it. Here we show that the mitochondria-shaping protein Opa1 participates in resistance against the tyrosine kinase inhibitor gefitinib in a lung adenoca...

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Detalles Bibliográficos
Autores principales: Noguchi, Masafumi, Kohno, Susumu, Pellattiero, Anna, Machida, Yukino, Shibata, Keitaro, Shintani, Norihito, Kohno, Takashi, Gotoh, Noriko, Takahashi, Chiaki, Hirao, Atsushi, Scorrano, Luca, Kasahara, Atsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076284/
https://www.ncbi.nlm.nih.gov/pubmed/37019897
http://dx.doi.org/10.1038/s41419-023-05768-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076284/
https://www.ncbi.nlm.nih.gov/pubmed/37019897
http://dx.doi.org/10.1038/s41419-023-05768-2

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