Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models

Transcriptional changes in Rett syndrome (RTT) are assumed to directly correlate with steady-state mRNA levels, but limited evidence in mice suggests that changes in transcription can be compensated by post-transcriptional regulation. We measure transcription rate and mRNA half-life changes in RTT p...

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Detalles Bibliográficos
Autores principales: Rodrigues, Deivid C., Mufteev, Marat, Yuki, Kyoko E., Narula, Ashrut, Wei, Wei, Piekna, Alina, Liu, Jiajie, Pasceri, Peter, Rissland, Olivia S., Wilson, Michael D., Ellis, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076348/
https://www.ncbi.nlm.nih.gov/pubmed/37019888
http://dx.doi.org/10.1038/s41467-023-37339-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076348/
https://www.ncbi.nlm.nih.gov/pubmed/37019888
http://dx.doi.org/10.1038/s41467-023-37339-6

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