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Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models
Transcriptional changes in Rett syndrome (RTT) are assumed to directly correlate with steady-state mRNA levels, but limited evidence in mice suggests that changes in transcription can be compensated by post-transcriptional regulation. We measure transcription rate and mRNA half-life changes in RTT p...
Autores principales: | Rodrigues, Deivid C., Mufteev, Marat, Yuki, Kyoko E., Narula, Ashrut, Wei, Wei, Piekna, Alina, Liu, Jiajie, Pasceri, Peter, Rissland, Olivia S., Wilson, Michael D., Ellis, James |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076348/ https://www.ncbi.nlm.nih.gov/pubmed/37019888 http://dx.doi.org/10.1038/s41467-023-37339-6 |
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