ERK MAPK signaling pathway inhibition as a potential target to prevent autophagy alterations in Spinal Muscular Atrophy motoneurons

Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) protein. SMN reduction induces spinal cord motoneuron (MN) degeneration, which leads to progressive muscular atrophy and weakness. The l...

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Detalles Bibliográficos
Autores principales: Sansa, Alba, Miralles, Maria P., Beltran, Maria, Celma-Nos, Ferran, Calderó, Jordi, Garcera, Ana, Soler, Rosa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076363/
https://www.ncbi.nlm.nih.gov/pubmed/37019880
http://dx.doi.org/10.1038/s41420-023-01409-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076363/
https://www.ncbi.nlm.nih.gov/pubmed/37019880
http://dx.doi.org/10.1038/s41420-023-01409-x

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