Ensemble of structure and ligand-based classification models for hERG liability profiling

Drug-induced cardiotoxicity represents one of the most critical safety concerns in the early stages of drug development. The blockade of the human ether-à-go-go-related potassium channel (hERG) is the most frequent cause of cardiotoxicity, as it is associated to long QT syndrome which can lead to fa...

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Detalles Bibliográficos
Autores principales: Vittorio, Serena, Lunghini, Filippo, Pedretti, Alessandro, Vistoli, Giulio, Beccari, Andrea R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076575/
https://www.ncbi.nlm.nih.gov/pubmed/37033661
http://dx.doi.org/10.3389/fphar.2023.1148670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076575/
https://www.ncbi.nlm.nih.gov/pubmed/37033661
http://dx.doi.org/10.3389/fphar.2023.1148670

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