The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation

Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine uptake by inhibiting the System Xc-, leading to int...

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Detalles Bibliográficos
Autores principales: Fan, Genhao, Liu, Menglin, Liu, Jia, Huang, Yuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076579/
https://www.ncbi.nlm.nih.gov/pubmed/37033381
http://dx.doi.org/10.3389/fnmol.2023.1113081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076579/
https://www.ncbi.nlm.nih.gov/pubmed/37033381
http://dx.doi.org/10.3389/fnmol.2023.1113081

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