Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data

Introduction: A physiologically based biokinetic model for di (2-ethylhexyl) adipate (DEHA) based on a refined model for di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the metabolism and biokinetics of DEHA following a single oral dosage of 50 mg to two male and two female volunteer...

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Detalles Bibliográficos
Autores principales: McNally, Kevin, Sams, Craig, Loizou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076754/
https://www.ncbi.nlm.nih.gov/pubmed/37033641
http://dx.doi.org/10.3389/fphar.2023.1165770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076754/
https://www.ncbi.nlm.nih.gov/pubmed/37033641
http://dx.doi.org/10.3389/fphar.2023.1165770

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