Voltage-gated calcium channel subunit α(2)δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury

Neuropathic pain, an intractable pain symptom that occurs after nerve damage, is caused by the aberrant excitability of spinal dorsal horn (SDH) neurons. Gabapentinoids, the most commonly used drugs for neuropathic pain, inhibit spinal calcium-mediated neurotransmitter release by binding to α(2)δ-1,...

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Detalles Bibliográficos
Autores principales: Koga, Keisuke, Kobayashi, Kenta, Tsuda, Makoto, Kubota, Kazufumi, Kitano, Yutaka, Furue, Hidemasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076860/
https://www.ncbi.nlm.nih.gov/pubmed/37033377
http://dx.doi.org/10.3389/fnmol.2023.1099925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076860/
https://www.ncbi.nlm.nih.gov/pubmed/37033377
http://dx.doi.org/10.3389/fnmol.2023.1099925

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