Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells

All-trans-retinoic acid (ATRA)-based differentiation therapy of acute promyelocytic leukemia (APL) represents one of the most clinically effective examples of precision medicine and the first example of targeted oncoprotein degradation. The success of ATRA in APL, however, remains to be translated t...

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Detalles Bibliográficos
Autores principales: Sbirkov, Y., Schenk, T., Kwok, C., Stengel, S., Brown, R., Brown, G., Chesler, L., Zelent, A., Fuchter, M. J., Petrie, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076884/
https://www.ncbi.nlm.nih.gov/pubmed/37035245
http://dx.doi.org/10.3389/fcell.2023.1076458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076884/
https://www.ncbi.nlm.nih.gov/pubmed/37035245
http://dx.doi.org/10.3389/fcell.2023.1076458

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