An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses

Antigen display on the surface of Virus-Like Particles (VLPs) improves immunogenicity compared to soluble proteins. We hypothesised that immune responses can be further improved by increasing the antigen density on the surface of VLPs. In this work, we report an HIV-1 Gag-based VLP platform engineer...

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Detalles Bibliográficos
Autores principales: Tarrés-Freixas, Ferran, Aguilar-Gurrieri, Carmen, Rodríguez de la Concepción, María Luisa, Urrea, Victor, Trinité, Benjamin, Ortiz, Raquel, Pradenas, Edwards, Blanco, Pau, Marfil, Sílvia, Molinos-Albert, Luis Manuel, Barajas, Ana, Pons-Grífols, Anna, Ávila-Nieto, Carlos, Varela, Ismael, Cervera, Laura, Gutiérrez-Granados, Sònia, Segura, María Mercedes, Gòdia, Francesc, Clotet, Bonaventura, Carrillo, Jorge, Blanco, Julià
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077320/
https://www.ncbi.nlm.nih.gov/pubmed/37024469
http://dx.doi.org/10.1038/s41541-023-00648-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077320/
https://www.ncbi.nlm.nih.gov/pubmed/37024469
http://dx.doi.org/10.1038/s41541-023-00648-4

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