Defective jagged-1 signaling affects GnRH development and contributes to congenital hypogonadotropic hypogonadism

In vertebrate species, fertility is controlled by gonadotropin-releasing hormone (GnRH) neurons. GnRH cells arise outside the central nervous system, in the developing olfactory pit, and migrate along olfactory/vomeronasal/terminal nerve axons into the forebrain during embryonic development. Congeni...

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Detalles Bibliográficos
Autores principales: Cotellessa, Ludovica, Marelli, Federica, Duminuco, Paolo, Adamo, Michela, Papadakis, Georgios E., Bartoloni, Lucia, Sato, Naoko, Lang-Muritano, Mariarosaria, Troendle, Amineh, Dhillo, Waljit S., Morelli, Annamaria, Guarnieri, Giulia, Pitteloud, Nelly, Persani, Luca, Bonomi, Marco, Giacobini, Paolo, Vezzoli, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077483/
https://www.ncbi.nlm.nih.gov/pubmed/36729644
http://dx.doi.org/10.1172/jci.insight.161998

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