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Structure-Based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance

[Image: see text] The search for antibiotics that function through novel mechanisms of action is ongoing, and recent progress in our lab identified the tricarboxylic acid cycle as a viable option. Promysalin is a secondary metabolite capable of species-specific inhibition of Pseudomonas aeruginosa,...

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Detalles Bibliográficos
Autores principales: Mahoney, Andrew R., Storek, Kelly M., Wuest, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077553/
https://www.ncbi.nlm.nih.gov/pubmed/37033834
http://dx.doi.org/10.1021/acsomega.3c00884