New TSPO Crystal Structures of Mutant and Heme-Bound Forms with Altered Flexibility, Ligand Binding, and Porphyrin Degradation Activity

[Image: see text] The ancient protein TSPO (translocator protein 18kD) is found in all kingdoms and was originally identified as a binding site of benzodiazepine drugs. Its physiological function remains unclear, although porphyrins are conserved ligands. Several crystal structures of bacterial TSPO...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Hiser, Carrie, Li, Fei, Hall, Robert, Garavito, R. Michael, Ferguson-Miller, Shelagh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077581/
https://www.ncbi.nlm.nih.gov/pubmed/36947867
http://dx.doi.org/10.1021/acs.biochem.2c00612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077581/
https://www.ncbi.nlm.nih.gov/pubmed/36947867
http://dx.doi.org/10.1021/acs.biochem.2c00612

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