The N‐Acetylgalactosamine‐conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low‐density lipoprotein cholesterol reductions

Inclisiran, a small interfering RNA, selectively inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis in the liver and has been shown to reduce low‐density lipoprotein cholesterol (LDL‐C) by ≥50% in patients with hypercholesterolemia receiving maximally tolerated statins. The tox...

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Detalles Bibliográficos
Autores principales: Lehoux, Dario, Kallend, David, Wijngaard, Peter L. J., Brown, Alan P., Zerler, Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077952/
https://www.ncbi.nlm.nih.gov/pubmed/37021909
http://dx.doi.org/10.1002/prp2.1080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077952/
https://www.ncbi.nlm.nih.gov/pubmed/37021909
http://dx.doi.org/10.1002/prp2.1080

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