TREM2(+) and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

The immunopathological mechanisms driving the development of severe COVID-19 remain poorly defined. Here, we utilize a rhesus macaque model of acute SARS-CoV-2 infection to delineate perturbations in the innate immune system. SARS-CoV-2 initiates a rapid infiltration of plasmacytoid dendritic cells...

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Detalles Bibliográficos
Autores principales: Upadhyay, Amit A., Viox, Elise G., Hoang, Timothy N., Boddapati, Arun K., Pino, Maria, Lee, Michelle Y.-H., Corry, Jacqueline, Strongin, Zachary, Cowan, David A., Beagle, Elizabeth N., Horton, Tristan R., Hamilton, Sydney, Aoued, Hadj, Harper, Justin L., Edwards, Christopher T., Nguyen, Kevin, Pellegrini, Kathryn L., Tharp, Gregory K., Piantadosi, Anne, Levit, Rebecca D., Amara, Rama R., Barratt-Boyes, Simon M., Ribeiro, Susan P., Sekaly, Rafick P., Vanderford, Thomas H., Schinazi, Raymond F., Paiardini, Mirko, Bosinger, Steven E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078029/
https://www.ncbi.nlm.nih.gov/pubmed/37024448
http://dx.doi.org/10.1038/s41467-023-37425-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078029/
https://www.ncbi.nlm.nih.gov/pubmed/37024448
http://dx.doi.org/10.1038/s41467-023-37425-9

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