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Targeting a KRAS i‐motif forming sequence by unmodified and gamma‐modified peptide nucleic acid oligomers
Growing interest in i‐motif DNA as a transcriptional regulatory element motivates development of synthetic molecules capable of targeting these structures. In this study, we designed unmodified peptide nucleic acid (PNA) and gamma‐modified PNA (γPNA) oligomers complementary to an i‐motif forming seq...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078108/ https://www.ncbi.nlm.nih.gov/pubmed/36573547 http://dx.doi.org/10.1002/bip.23529 |