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Enhancers display constrained sequence flexibility and context-specific modulation of motif function

The information about when and where each gene is to be expressed is mainly encoded in the DNA sequence of enhancers, sequence elements that comprise binding sites (motifs) for different transcription factors (TFs). Most of the research on enhancer sequences has been focused on TF motif presence, wh...

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Detalles Bibliográficos
Autores principales: Reiter, Franziska, de Almeida, Bernardo P., Stark, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078294/
https://www.ncbi.nlm.nih.gov/pubmed/36941077
http://dx.doi.org/10.1101/gr.277246.122