Automated optimisation of solubility and conformational stability of antibodies and proteins

Biologics, such as antibodies and enzymes, are crucial in research, biotechnology, diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but their development is impeded by developability issues. Stability and solubility are key biophysical traits underpinning d...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosace, Angelo, Bennett, Anja, Oeller, Marc, Mortensen, Mie M., Sakhnini, Laila, Lorenzen, Nikolai, Poulsen, Christian, Sormanni, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079162/
https://www.ncbi.nlm.nih.gov/pubmed/37024501
http://dx.doi.org/10.1038/s41467-023-37668-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079162/
https://www.ncbi.nlm.nih.gov/pubmed/37024501
http://dx.doi.org/10.1038/s41467-023-37668-6

Ejemplares similares