On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify the effect on the parasite target

Cryptosporidium parvum is a globally distributed zoonotic protozoan parasite that causes moderate to severe, sometime deadly, watery diarrhea in humans and animals, for which fully effective treatments are yet unavailable. In studying the mechanism of action of drugs against intracellular pathogens,...

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Detalles Bibliográficos
Autores principales: Yang, Bo, Yan, Yueyang, Wang, Dongqiang, Zhang, Ying, Yin, Jigang, Zhu, Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079235/
https://www.ncbi.nlm.nih.gov/pubmed/36972284
http://dx.doi.org/10.1371/journal.pntd.0011217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079235/
https://www.ncbi.nlm.nih.gov/pubmed/36972284
http://dx.doi.org/10.1371/journal.pntd.0011217

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