Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies

Combination therapies targeting malignancies aim to increase treatment efficacy and reduce toxicity. Hypomethylating drug 5-Aza-2’-deoxycytidine (5-Aza-2’) enhances transcription of tumor suppressor genes and induces replication errors via entrapment of DNMT1, yielding DNA-protein crosslinks. Post-t...

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Detalles Bibliográficos
Autores principales: Kroonen, Jessie S., de Graaf, Ilona J., Kumar, Sumit, Remst, Dennis F. G., Wouters, Anne K., Heemskerk, Mirjam H. M., Vertegaal, Alfred C. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079526/
https://www.ncbi.nlm.nih.gov/pubmed/36792656
http://dx.doi.org/10.1038/s41375-023-01838-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079526/
https://www.ncbi.nlm.nih.gov/pubmed/36792656
http://dx.doi.org/10.1038/s41375-023-01838-8

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