Human gene-engineered calreticulin mutant stem cells recapitulate MPN hallmarks and identify targetable vulnerabilities

Calreticulin (CALR) mutations present the main oncogenic drivers in JAK2 wildtype (WT) myeloproliferative neoplasms (MPN), including essential thrombocythemia and myelofibrosis, where mutant (MUT) CALR is increasingly recognized as a suitable mutation-specific drug target. However, our current under...

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Detalles Bibliográficos
Autores principales: Foßelteder, Johannes, Pabst, Gabriel, Sconocchia, Tommaso, Schlacher, Angelika, Auinger, Lisa, Kashofer, Karl, Beham-Schmid, Christine, Trajanoski, Slave, Waskow, Claudia, Schöll, Wolfgang, Sill, Heinz, Zebisch, Armin, Wölfler, Albert, Thomas, Daniel, Reinisch, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079532/
https://www.ncbi.nlm.nih.gov/pubmed/36813992
http://dx.doi.org/10.1038/s41375-023-01848-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079532/
https://www.ncbi.nlm.nih.gov/pubmed/36813992
http://dx.doi.org/10.1038/s41375-023-01848-6

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