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Human gene-engineered calreticulin mutant stem cells recapitulate MPN hallmarks and identify targetable vulnerabilities
Calreticulin (CALR) mutations present the main oncogenic drivers in JAK2 wildtype (WT) myeloproliferative neoplasms (MPN), including essential thrombocythemia and myelofibrosis, where mutant (MUT) CALR is increasingly recognized as a suitable mutation-specific drug target. However, our current under...
Autores principales: | Foßelteder, Johannes, Pabst, Gabriel, Sconocchia, Tommaso, Schlacher, Angelika, Auinger, Lisa, Kashofer, Karl, Beham-Schmid, Christine, Trajanoski, Slave, Waskow, Claudia, Schöll, Wolfgang, Sill, Heinz, Zebisch, Armin, Wölfler, Albert, Thomas, Daniel, Reinisch, Andreas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079532/ https://www.ncbi.nlm.nih.gov/pubmed/36813992 http://dx.doi.org/10.1038/s41375-023-01848-6 |
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