Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer

Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a major challenge for clinicians and patients with non-small cell lung cancer (NSCLC). Serine-arginine protein kinase 1 (SRPK1) is a key oncoprotein in the EGFR/AKT pathway that participates in tumorigenesis....

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Detalles Bibliográficos
Autores principales: Huang, Jing-Qiang, Duan, Ling-Xin, Liu, Qiu-Yu, Li, He-Feng, Hu, Ao-Ping, Song, Jun-Wei, Lin, Chuxuan, Huang, Bingsheng, Yao, Da, Peng, Bin, Sun, Yehong, Wen, Yuxin, Yang, Lin, Xu, Xingzhi, Gong, Li-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079535/
https://www.ncbi.nlm.nih.gov/pubmed/36869126
http://dx.doi.org/10.1038/s41388-023-02645-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079535/
https://www.ncbi.nlm.nih.gov/pubmed/36869126
http://dx.doi.org/10.1038/s41388-023-02645-2

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