Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis

Highly effective drugs modulating the defective protein encoded by the CFTR gene have revolutionized cystic fibrosis (CF) therapy. Preclinical drug-testing on human nasal epithelial (HNE) cell cultures and 3-dimensional human intestinal organoids (3D HIO) are used to address patient-specific variati...

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Detalles Bibliográficos
Autores principales: Birimberg-Schwartz, Liron, Ip, Wan, Bartlett, Claire, Avolio, Julie, Vonk, Annelotte M, Gunawardena, Tarini, Du, Kai, Esmaeili, Mohsen, Beekman, Jeffrey M, Rommens, Johanna, Strug, Lisa, Bear, Christine E, Moraes, Theo J, Gonska, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079552/
https://www.ncbi.nlm.nih.gov/pubmed/37024122
http://dx.doi.org/10.26508/lsa.202201857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079552/
https://www.ncbi.nlm.nih.gov/pubmed/37024122
http://dx.doi.org/10.26508/lsa.202201857

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