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SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients

Patients with COVID-19 may develop abnormal inflammatory response, followed in some cases by severe disease and long-lasting syndromes. We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) i...

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Autores principales: Charvet, Benjamin, Brunel, Joanna, Pierquin, Justine, Iampietro, Mathieu, Decimo, Didier, Queruel, Nelly, Lucas, Alexandre, Encabo-Berzosa, María del Mar, Arenaz, Izaskun, Marmolejo, Tania Perez, Gonzalez, Arturo Ivan, Maldonado, Armando Castorena, Mathieu, Cyrille, Küry, Patrick, Flores-Rivera, Jose, Torres-Ruiz, Fernanda, Avila-Rios, Santiago, Salgado Montes de Oca, Gonzalo, Schoorlemmer, Jon, Perron, Hervé, Horvat, Branka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079620/
https://www.ncbi.nlm.nih.gov/pubmed/37091988
http://dx.doi.org/10.1016/j.isci.2023.106604
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author Charvet, Benjamin
Brunel, Joanna
Pierquin, Justine
Iampietro, Mathieu
Decimo, Didier
Queruel, Nelly
Lucas, Alexandre
Encabo-Berzosa, María del Mar
Arenaz, Izaskun
Marmolejo, Tania Perez
Gonzalez, Arturo Ivan
Maldonado, Armando Castorena
Mathieu, Cyrille
Küry, Patrick
Flores-Rivera, Jose
Torres-Ruiz, Fernanda
Avila-Rios, Santiago
Salgado Montes de Oca, Gonzalo
Schoorlemmer, Jon
Perron, Hervé
Horvat, Branka
author_facet Charvet, Benjamin
Brunel, Joanna
Pierquin, Justine
Iampietro, Mathieu
Decimo, Didier
Queruel, Nelly
Lucas, Alexandre
Encabo-Berzosa, María del Mar
Arenaz, Izaskun
Marmolejo, Tania Perez
Gonzalez, Arturo Ivan
Maldonado, Armando Castorena
Mathieu, Cyrille
Küry, Patrick
Flores-Rivera, Jose
Torres-Ruiz, Fernanda
Avila-Rios, Santiago
Salgado Montes de Oca, Gonzalo
Schoorlemmer, Jon
Perron, Hervé
Horvat, Branka
author_sort Charvet, Benjamin
collection PubMed
description Patients with COVID-19 may develop abnormal inflammatory response, followed in some cases by severe disease and long-lasting syndromes. We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner. Plasma and/or sera of 221 COVID-19 patients from different cohorts, infected with successive SARS-CoV-2 variants including the Omicron, had detectable HERV-W ENV, which correlated with ENV expression in T lymphocytes and peaked with the disease severity. HERV-W ENV was also found in postmortem tissues of lungs, heart, gastrointestinal tract, brain olfactory bulb, and nasal mucosa from COVID-19 patients. Altogether, these results demonstrate that SARS-CoV-2 could induce HERV-W envelope protein expression and suggest its involvement in the immunopathogenesis of certain COVID-19-associated syndromes and thereby its relevance in the development of personalized treatment of patients.
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spelling pubmed-100796202023-04-07 SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients Charvet, Benjamin Brunel, Joanna Pierquin, Justine Iampietro, Mathieu Decimo, Didier Queruel, Nelly Lucas, Alexandre Encabo-Berzosa, María del Mar Arenaz, Izaskun Marmolejo, Tania Perez Gonzalez, Arturo Ivan Maldonado, Armando Castorena Mathieu, Cyrille Küry, Patrick Flores-Rivera, Jose Torres-Ruiz, Fernanda Avila-Rios, Santiago Salgado Montes de Oca, Gonzalo Schoorlemmer, Jon Perron, Hervé Horvat, Branka iScience Article Patients with COVID-19 may develop abnormal inflammatory response, followed in some cases by severe disease and long-lasting syndromes. We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner. Plasma and/or sera of 221 COVID-19 patients from different cohorts, infected with successive SARS-CoV-2 variants including the Omicron, had detectable HERV-W ENV, which correlated with ENV expression in T lymphocytes and peaked with the disease severity. HERV-W ENV was also found in postmortem tissues of lungs, heart, gastrointestinal tract, brain olfactory bulb, and nasal mucosa from COVID-19 patients. Altogether, these results demonstrate that SARS-CoV-2 could induce HERV-W envelope protein expression and suggest its involvement in the immunopathogenesis of certain COVID-19-associated syndromes and thereby its relevance in the development of personalized treatment of patients. Elsevier 2023-04-07 /pmc/articles/PMC10079620/ /pubmed/37091988 http://dx.doi.org/10.1016/j.isci.2023.106604 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Charvet, Benjamin
Brunel, Joanna
Pierquin, Justine
Iampietro, Mathieu
Decimo, Didier
Queruel, Nelly
Lucas, Alexandre
Encabo-Berzosa, María del Mar
Arenaz, Izaskun
Marmolejo, Tania Perez
Gonzalez, Arturo Ivan
Maldonado, Armando Castorena
Mathieu, Cyrille
Küry, Patrick
Flores-Rivera, Jose
Torres-Ruiz, Fernanda
Avila-Rios, Santiago
Salgado Montes de Oca, Gonzalo
Schoorlemmer, Jon
Perron, Hervé
Horvat, Branka
SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients
title SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients
title_full SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients
title_fullStr SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients
title_full_unstemmed SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients
title_short SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients
title_sort sars-cov-2 awakens ancient retroviral genes and the expression of proinflammatory herv-w envelope protein in covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079620/
https://www.ncbi.nlm.nih.gov/pubmed/37091988
http://dx.doi.org/10.1016/j.isci.2023.106604
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