Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation

SHP2 is a phosphatase/adaptor protein that plays an important role in various signaling pathways. Its mutations are associated with cancers and developmental diseases. SHP2 contains a protein tyrosine phosphatase (PTP) and two SH2 domains. Selective inhibition of these domains has been challenging d...

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Detalles Bibliográficos
Autores principales: Sha, Fern, Kurosawa, Kohei, Glasser, Eliezra, Ketavarapu, Gayatri, Albazzaz, Samara, Koide, Akiko, Koide, Shohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079645/
https://www.ncbi.nlm.nih.gov/pubmed/36806475
http://dx.doi.org/10.1016/j.jmb.2023.168010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079645/
https://www.ncbi.nlm.nih.gov/pubmed/36806475
http://dx.doi.org/10.1016/j.jmb.2023.168010

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