Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

Since Mdm2 (Mouse double minute 2) inhibitors show serious toxicity in clinic studies, different approaches to achieve therapeutic reactivation of p53-mediated tumor suppression in cancers need to be explored. Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding...

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Detalles Bibliográficos
Autores principales: Yi, Jingjie, Tavana, Omid, Li, Huan, Wang, Donglai, Baer, Richard J., Gu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079682/
https://www.ncbi.nlm.nih.gov/pubmed/37024504
http://dx.doi.org/10.1038/s41467-023-37617-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079682/
https://www.ncbi.nlm.nih.gov/pubmed/37024504
http://dx.doi.org/10.1038/s41467-023-37617-3

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