Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

Topoisomerase IIIα (TOP3A) belongs to the conserved Type IA family of DNA topoisomerases. Here we report that human TOP3A is associated with DNA replication forks and that a “self-trapping” TOP3A mutant (TOP3A-R364W) generates cellular TOP3A DNA cleavage complexes (TOP3Accs). We show that trapped TO...

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Detalles Bibliográficos
Autores principales: Saha, Liton Kumar, Saha, Sourav, Yang, Xi, Huang, Shar-yin Naomi, Sun, Yilun, Jo, Ukhyun, Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079683/
https://www.ncbi.nlm.nih.gov/pubmed/37024461
http://dx.doi.org/10.1038/s41467-023-37498-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079683/
https://www.ncbi.nlm.nih.gov/pubmed/37024461
http://dx.doi.org/10.1038/s41467-023-37498-6

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