Disease modeling of ADAMTS9-related nephropathy using kidney organoids reveals its roles in tubular cells and podocytes

INTRODUCTION: Mutations in ADAMTS9 cause nephronophthisis-related ciliopathies (NPHP-RC), which are characterized by multiple developmental defects and kidney diseases. Patients with NPHP-RC usually have normal glomeruli and negligible or no proteinuria. Herein, we identified novel compound-heterozy...

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Detalles Bibliográficos
Autores principales: Yu, Seyoung, Choi, Yo Jun, Rim, John Hoon, Kim, Hye-Youn, Bekheirnia, Nasim, Swartz, Sarah Jane, Dai, Hongzheng, Gu, Shen Linda, Lee, Soyeon, Nishinakamura, Ryuichi, Hildebrandt, Friedhelm, Bekheirnia, Mir Reza, Gee, Heon Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079903/
https://www.ncbi.nlm.nih.gov/pubmed/37035301
http://dx.doi.org/10.3389/fmed.2023.1089159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079903/
https://www.ncbi.nlm.nih.gov/pubmed/37035301
http://dx.doi.org/10.3389/fmed.2023.1089159

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