Aberrant Cyclin D1 splicing in cancer: from molecular mechanism to therapeutic modulation

Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, possesses many mutation types with different mutation frequencies in human cancers. The G870A mutation is the most common mutation in CCND1, which produces two isoforms: full-length CCND1a and divergent C-terminal CCND1b. The dysregula...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Su, Wei, Zhang, Taotao, Zhang, Shasha, Lei, Huiwen, Ma, Fengdie, Shi, Maoning, Shi, Wenjing, Xie, Xiaodong, Di, Cuixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079974/
https://www.ncbi.nlm.nih.gov/pubmed/37024471
http://dx.doi.org/10.1038/s41419-023-05763-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079974/
https://www.ncbi.nlm.nih.gov/pubmed/37024471
http://dx.doi.org/10.1038/s41419-023-05763-7

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