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Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques

Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.S, are boosted with Ad26.COV2.S, Ad26.COV2.S.529 (encoding Omicron BA.1 S) or a 1:1 combination of both...

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Detalles Bibliográficos
Autores principales: Solforosi, Laura, Costes, Lea M. M., Tolboom, Jeroen T. B. M., McMahan, Katherine, Anioke, Tochi, Hope, David, Murdza, Tetyana, Sciacca, Michaela, Bouffard, Emily, Barrett, Julia, Wu, Cindy, Hachmann, Nicole, Miller, Jessica, Yu, Jingyou, He, Xuan, Jacob-Dolan, Catherine, Huber, Sietske K. Rosendahl, Dekking, Liesbeth, Chamanza, Ronnie, Choi, Ying, Boer, Karin Feddes-de, Barouch, Dan H., Schuitemaker, Hanneke, Zahn, Roland C., Wegmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080532/
https://www.ncbi.nlm.nih.gov/pubmed/37029141
http://dx.doi.org/10.1038/s41467-023-37715-2