Cargando…

Conformational Selection of a Tryptophan Side Chain Drives the Generalized Increase in Activity of PET Hydrolases through a Ser/Ile Double Mutation

[Image: see text] Poly(ethylene terephthalate) (PET) is the most common polyester plastic in the packaging industry and a major source of environmental pollution due to its single use. Several enzymes, termed PET hydrolases, have been found to hydrolyze this polymer at different temperatures, with t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crnjar, Alessandro, Griñen, Aransa, Kamerlin, Shina C. L., Ramírez-Sarmiento, César A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080609/ https://www.ncbi.nlm.nih.gov/pubmed/37035283 http://dx.doi.org/10.1021/acsorginorgau.2c00054

Ejemplares similares

Conformational diversity and enantioconvergence in potato epoxide hydrolase 1
por: Bauer, P., et al.
Publicado: (2016)

Probing the mechanisms for the selectivity and promiscuity of methyl parathion hydrolase
por: Purg, Miha, et al.
Publicado: (2016)

Harnessing Conformational Plasticity to Generate Designer Enzymes
por: Crean, Rory M., et al.
Publicado: (2020)

Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase
por: Kulkarni, Yashraj S., et al.
Publicado: (2019)

Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes
por: Amrein, Beat A., et al.
Publicado: (2015)

Common polymorphism (81Val>Ile) and rare mutations (257Arg>Ser and 335Ile>Ser) of the MC3R gene in obese Polish children and adolescents
por: Cieslak, J., et al.
Publicado: (2013)

Tryptophan Side-Chain Oxidase Enzyme Suppresses Hepatocellular Carcinoma Growth through Degradation of Tryptophan
por: Ai, Yang, et al.
Publicado: (2021)

Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (βα)(8) Barrel Enzymes of Histidine and Tryptophan Biosynthesis
por: Romero-Rivera, Adrian, et al.
Publicado: (2022)

The role of ligand-gated conformational changes in enzyme catalysis
por: Moreira, Cátia, et al.
Publicado: (2019)

Tryptophan Analogues with Fixed Side‐Chain Orientation: Expanding the Scope
por: Nicke, Lennart, et al.
Publicado: (2020)

Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of l-tryptophan
por: Sprenger, Janina, et al.
Publicado: (2021)

On Side-Chain Conformational Entropy of Proteins
por: Zhang, Jinfeng, et al.
Publicado: (2006)

Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase
por: Mhashal, Anil R., et al.
Publicado: (2020)

Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily
por: Barrozo, Alexandre, et al.
Publicado: (2015)

Fast and accurate prediction of protein side-chain conformations
por: Liang, Shide, et al.
Publicado: (2011)

Side Chain Conformational Averaging in Human Dihydrofolate Reductase
por: Tuttle, Lisa M., et al.
Publicado: (2014)

Quantifying side-chain conformational variations in protein structure
por: Miao, Zhichao, et al.
Publicado: (2016)

Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors
por: Tseng, Po‐Sen, et al.
Publicado: (2023)

The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem
por: Moriyasu, Kazuki, et al.
Publicado: (2016)

Discovery and rational engineering of PET hydrolase with both mesophilic and thermophilic PET hydrolase properties
por: Hong, Hwaseok, et al.
Publicado: (2023)

Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase
por: Kulkarni, Yashraj S., et al.
Publicado: (2018)

Ligand binding remodels protein side-chain conformational heterogeneity
por: Wankowicz, Stephanie A, et al.
Publicado: (2022)

Where are the female science professors? A personal perspective
por: Kamerlin, Shina Caroline Lynn
Publicado: (2016)

Side Chain Orientation of Tryptophan Analogues Determines Agonism and Inverse Agonism in Short Ghrelin Peptides
por: Nicke, Lennart, et al.
Publicado: (2019)

The Val34Met, Thr164Ile and Ser220Cys Polymorphisms of the β2-Adrenergic Receptor and Their Consequences on the Receptor Conformational Features: A Molecular Dynamics Simulation Study
por: Archala, Aneta, et al.
Publicado: (2022)

The N-terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition
por: Corbella, Marina, et al.
Publicado: (2021)

Correlation analysis of the side-chains conformational distribution in bound and unbound proteins
por: Kirys, Tatsiana, et al.
Publicado: (2012)

Side-Chain Polarity Modulates the Intrinsic Conformational Landscape of Model Dipeptides
por: Chakraborty, Debayan, et al.
Publicado: (2021)

Simultaneous prediction of antibody backbone and side-chain conformations with deep learning
por: Akpinaroglu, Deniz, et al.
Publicado: (2022)

Exceptionally large entropy contributions enable the high rates of GTP hydrolysis on the ribosome
por: Åqvist, Johan, et al.
Publicado: (2015)

A Structural View into the Complexity of Carbon Dioxide Fixation
por: Kourist, Robert, et al.
Publicado: (2022)

Low Carbon Footprint Recycling of Post‐Consumer PET Plastic with a Metagenomic Polyester Hydrolase
por: Sonnendecker, Christian, et al.
Publicado: (2022)

Role of Tryptophan Side Chain Dynamics on the Trp-Cage Mini-Protein Folding Studied by Molecular Dynamics Simulations
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2014)

Pentapeptides for the treatment of small cell lung cancer: Optimisation by N(ind)-alkyl modification of the tryptophan side chain
por: Haitham Abusara, Osama, et al.
Publicado: (2017)

Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells
por: Percze, Krisztina, et al.
Publicado: (2023)

Fitmunk: improving protein structures by accurate, automatic modeling of side-chain conformations
por: Porebski, Przemyslaw Jerzy, et al.
Publicado: (2016)

Conformational Analysis of the Oligosaccharides Related to Side Chains of Holothurian Fucosylated Chondroitin Sulfates
por: Gerbst, Alexey G., et al.
Publicado: (2015)

Changes in conformational dynamics of basic side chains upon protein–DNA association
por: Esadze, Alexandre, et al.
Publicado: (2016)

An Algorithm for Computing Side Chain Conformational Variations of a Protein Tunnel/Channel
por: Seo, Udeok, et al.
Publicado: (2018)

Conformational exchange of aromatic side chains by (1)H CPMG relaxation dispersion
por: Raum, Heiner N., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mh1ub9s299aumdmk9dgckbp196