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Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
[Image: see text] A porous, nonsolvated polymorph of the voltage-gated sodium channel blocker mexiletine hydrochloride absorbs iodine vapor to give a pharmaceutical cocrystal incorporating an I(2)Cl(–) anion that forms a halogen−π interaction with the mexiletine cations. The most thermodynamically s...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080649/ https://www.ncbi.nlm.nih.gov/pubmed/37038401 http://dx.doi.org/10.1021/acs.cgd.2c01464 |