Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical

[Image: see text] A porous, nonsolvated polymorph of the voltage-gated sodium channel blocker mexiletine hydrochloride absorbs iodine vapor to give a pharmaceutical cocrystal incorporating an I(2)Cl(–) anion that forms a halogen−π interaction with the mexiletine cations. The most thermodynamically s...

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Autores principales: Andrews, Jessica L., Yufit, Dmitry S., McCabe, James F., Fox, Mark A., Steed, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080649/
https://www.ncbi.nlm.nih.gov/pubmed/37038401
http://dx.doi.org/10.1021/acs.cgd.2c01464
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author Andrews, Jessica L.
Yufit, Dmitry S.
McCabe, James F.
Fox, Mark A.
Steed, Jonathan W.
author_facet Andrews, Jessica L.
Yufit, Dmitry S.
McCabe, James F.
Fox, Mark A.
Steed, Jonathan W.
author_sort Andrews, Jessica L.
collection PubMed
description [Image: see text] A porous, nonsolvated polymorph of the voltage-gated sodium channel blocker mexiletine hydrochloride absorbs iodine vapor to give a pharmaceutical cocrystal incorporating an I(2)Cl(–) anion that forms a halogen−π interaction with the mexiletine cations. The most thermodynamically stable form of the compound does not absorb iodine. This example shows that vapor sorption is a potentially useful and underused tool for bringing about changes in pharmaceutical solid form as part of a solid form screening protocol.
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spelling pubmed-100806492023-04-08 Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical Andrews, Jessica L. Yufit, Dmitry S. McCabe, James F. Fox, Mark A. Steed, Jonathan W. Cryst Growth Des [Image: see text] A porous, nonsolvated polymorph of the voltage-gated sodium channel blocker mexiletine hydrochloride absorbs iodine vapor to give a pharmaceutical cocrystal incorporating an I(2)Cl(–) anion that forms a halogen−π interaction with the mexiletine cations. The most thermodynamically stable form of the compound does not absorb iodine. This example shows that vapor sorption is a potentially useful and underused tool for bringing about changes in pharmaceutical solid form as part of a solid form screening protocol. American Chemical Society 2023-02-28 /pmc/articles/PMC10080649/ /pubmed/37038401 http://dx.doi.org/10.1021/acs.cgd.2c01464 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Andrews, Jessica L.
Yufit, Dmitry S.
McCabe, James F.
Fox, Mark A.
Steed, Jonathan W.
Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
title Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
title_full Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
title_fullStr Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
title_full_unstemmed Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
title_short Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
title_sort vapor sorption and halogen-bond-induced solid-form rearrangement of a porous pharmaceutical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080649/
https://www.ncbi.nlm.nih.gov/pubmed/37038401
http://dx.doi.org/10.1021/acs.cgd.2c01464
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