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Sperm DNA methylation is predominantly stable in mice offspring born after transplantation of long-term cultured spermatogonial stem cells

BACKGROUND: Spermatogonial stem cell transplantation (SSCT) is proposed as a fertility therapy for childhood cancer survivors. SSCT starts with cryopreserving a testicular biopsy prior to gonadotoxic treatments such as cancer treatments. When the childhood cancer survivor reaches adulthood and desir...

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Detalles Bibliográficos
Autores principales: Serrano, Joana B., Tabeling, Nils C., de Winter-Korver, Cindy M., van Daalen, Saskia K. M., van Pelt, Ans M. M., Mulder, Callista L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080964/
https://www.ncbi.nlm.nih.gov/pubmed/37029425
http://dx.doi.org/10.1186/s13148-023-01469-x