Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

Gastroesophageal adenocarcinoma (GEA) is an aggressive, often lethal, malignancy that displays marked chromosomal instability (CIN). To understand adaptive responses that enable CIN, we analyzed paired normal, premalignant, and malignant gastric lesions from human specimens and a carcinogen-induced...

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Detalles Bibliográficos
Autores principales: Sahgal, Pranshu, Patil, Deepa T., Sztupinszki, Zsofia M., Tisza, Viktoria, Spisak, Sandor, Huffman, Brandon, Prosz, Aurel, Singh, Harshabad, Lazaro, Jean-Bernard, Szallasi, Zoltan, Cleary, James M., Sethi, Nilay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081209/
https://www.ncbi.nlm.nih.gov/pubmed/37034740
http://dx.doi.org/10.1101/2023.03.27.534412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081209/
https://www.ncbi.nlm.nih.gov/pubmed/37034740
http://dx.doi.org/10.1101/2023.03.27.534412

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