APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1

HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4(+) T lymphocytes and macrophages. Previous studies have demonstrated that the APOBEC3 (A3) family of proteins (at least A3D, A3F, A3G, and stable A3H haplotypes) contribute to HIV-1 restriction in CD4(+) T lymphocytes. Viru...

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Detalles Bibliográficos
Autores principales: Ikeda, Terumasa, Shimizu, Ryo, Nasser, Hesham, Carpenter, Michael A., Cheng, Adam Z., Brown, William L., Sauter, Daniel, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081227/
https://www.ncbi.nlm.nih.gov/pubmed/37034786
http://dx.doi.org/10.1101/2023.03.28.534666

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