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Mechanism of histone H2B monoubiquitination by Bre1
Monoubiquitination of histone H2BK120/123 plays multiple roles in regulating transcription, DNA replication and the DNA damage response. The structure of a nucleosome in complex with the dimeric RING E3 ligase, Bre1, reveals that one RING domain binds to the nucleosome acidic patch, where it can pos...
Autores principales: | Zhao, Fan, Hicks, Chad W., Wolberger, Cynthia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081246/ https://www.ncbi.nlm.nih.gov/pubmed/37034759 http://dx.doi.org/10.1101/2023.03.27.534461 |
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