Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo

Middle East respiratory syndrome coronavirus (MERS-CoV) causes zoonotic disease. Dromedary camels are the source of zoonotic infection. We identified a mutation of amino acid leucine to phenylalanine in the codon 232 position of the non-structural protein 6 (nsp6) (nsp6 L232F) that is repeatedly ass...

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Detalles Bibliográficos
Autores principales: So, Ray TY, Chu, Daniel KW, Hui, Kenrie PY, Mok, Chris KP, Sanyal, Sumana, Nicholls, John M, Ho, John C. W., Cheung, Man-chun, Ng, Ka-chun, Yeung, Hin-Wo, Chan, Michael CW, Poon, Leo LM, Zhao, Jincun, Peiris, Malik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081289/
https://www.ncbi.nlm.nih.gov/pubmed/37034576
http://dx.doi.org/10.1101/2023.03.27.534490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081289/
https://www.ncbi.nlm.nih.gov/pubmed/37034576
http://dx.doi.org/10.1101/2023.03.27.534490

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