S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness

SARS-CoV-2 variants bearing complex combinations of mutations that confer increased transmissibility, COVID-19 severity, and immune escape, were first detected after S:D614G had gone to fixation, and likely originated during persistent infection of immunocompromised hosts. To test the hypothesis tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Yurkovetskiy, Leonid, Egri, Shawn, Kurhade, Chaitanya, Diaz-Salinas, Marco A., Jaimes, Javier A., Nyalile, Thomas, Xie, Xuping, Choudhary, Manish C., Dauphin, Ann, Li, Jonathan Z., Munro, James B., Shi, Pei-Yong, Shen, Kuang, Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081308/
https://www.ncbi.nlm.nih.gov/pubmed/37034621
http://dx.doi.org/10.1101/2023.03.30.535005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081308/
https://www.ncbi.nlm.nih.gov/pubmed/37034621
http://dx.doi.org/10.1101/2023.03.30.535005

Ejemplares similares