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Mitochondrial stress response gene Clpp deficiency impairs oocyte competence and deteriorate cyclophosphamide-induced ovarian damage in young mice

Chemotherapy is extensively used to treat cancers and is often associated with ovarian damage and leads to premature ovarian insufficiency and infertility, while the role of mitochondria during ovarian damage with chemotherapy remains unknown. This study used a mouse model with oocyte-specific delet...

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Detalles Bibliográficos
Autores principales: Li, Guangxin, Gu, Jingkai, Zhou, Xiaomei, Wu, Ting, Li, Xian, Hua, Renwu, Hai, Zhuo, Xiao, Yuan, Su, Jiaping, Yeung, Willian S. B., Liu, Kui, Guo, Chenxi, Wang, Tianren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081448/
https://www.ncbi.nlm.nih.gov/pubmed/37033217
http://dx.doi.org/10.3389/fendo.2023.1122012