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Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers

Gating of voltage-dependent sodium channels involves coordinated movements of the voltage sensors in the voltage-sensing modules (VSMs) of the four domains (DI-DIV) in response to membrane depolarization. Zhu et al. have recently examined the effects of charge reversal substitutions at the VSM of do...

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Detalles Bibliográficos
Autores principales: Gurevitz, Michael, Zhorov, Boris S., Dong, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081521/
https://www.ncbi.nlm.nih.gov/pubmed/37034138
http://dx.doi.org/10.46439/neurobiology.4.021