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DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation

Cultured human pluripotent stem cells (hPSCs) grow as colonies that require breakdown into small clumps for further propagation. Although cell death mechanism by single-cell dissociation of hPSCs has been well defined, how hPSCs respond to the deadly stimulus and recover the original status remains...

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Detalles Bibliográficos
Autores principales: Yoo, Dae Hoon, Im, Young Sam, Oh, Ji Young, Gil, Dayeon, Kim, Yong-Ou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082014/
https://www.ncbi.nlm.nih.gov/pubmed/37029196
http://dx.doi.org/10.1038/s41598-023-32567-8