Oncogenic signaling is coupled to colorectal cancer cell differentiation state

Colorectal cancer progression is intrinsically linked to stepwise deregulation of the intestinal differentiation trajectory. In this process, sequential mutations of APC, KRAS, TP53, and SMAD4 enable oncogenic signaling and establish the hallmarks of cancer. Here, we use mass cytometry of isogenic h...

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Detalles Bibliográficos
Autores principales: Sell, Thomas, Klotz, Christian, Fischer, Matthias M., Astaburuaga-García, Rosario, Krug, Susanne, Drost, Jarno, Clevers, Hans, Sers, Christine, Morkel, Markus, Blüthgen, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082329/
https://www.ncbi.nlm.nih.gov/pubmed/37017636
http://dx.doi.org/10.1083/jcb.202204001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082329/
https://www.ncbi.nlm.nih.gov/pubmed/37017636
http://dx.doi.org/10.1083/jcb.202204001

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