Cargando…

Oncogenic signaling is coupled to colorectal cancer cell differentiation state

Colorectal cancer progression is intrinsically linked to stepwise deregulation of the intestinal differentiation trajectory. In this process, sequential mutations of APC, KRAS, TP53, and SMAD4 enable oncogenic signaling and establish the hallmarks of cancer. Here, we use mass cytometry of isogenic h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sell, Thomas, Klotz, Christian, Fischer, Matthias M., Astaburuaga-García, Rosario, Krug, Susanne, Drost, Jarno, Clevers, Hans, Sers, Christine, Morkel, Markus, Blüthgen, Nils
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082329/ https://www.ncbi.nlm.nih.gov/pubmed/37017636 http://dx.doi.org/10.1083/jcb.202204001

Ejemplares similares

Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance
por: Morkel, Markus, et al.
Publicado: (2015)

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
por: Riemer, Pamela, et al.
Publicado: (2017)

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
por: Brandt, Raphael, et al.
Publicado: (2019)

Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS
por: Stelniec-Klotz, Iwona, et al.
Publicado: (2012)

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe
por: Gastl, Bastian, et al.
Publicado: (2020)

Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer
por: Uhlitz, Florian, et al.
Publicado: (2021)

Xenograft and organoid model systems in cancer research
por: Bleijs, Margit, et al.
Publicado: (2019)

Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling
por: Möller, Yvonne, et al.
Publicado: (2016)

Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression
por: Mamlouk, Soulafa, et al.
Publicado: (2020)

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells
por: Jürchott, Karsten, et al.
Publicado: (2010)

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2016)

Organoid culture systems for prostate epithelial tissue and prostate cancer tissue
por: Drost, Jarno, et al.
Publicado: (2016)

Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis
por: Aguilar, Carmen, et al.
Publicado: (2022)

Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer
por: Roßner, F, et al.
Publicado: (2016)

Cell hierarchies in colorectal cancer: focus on APC and BRAF
por: Morkel, Markus, et al.
Publicado: (2015)

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma
por: Bischoff, Philip, et al.
Publicado: (2021)

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
por: Mizutani, Tomohiro, et al.
Publicado: (2017)

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS(G12D) glycolytic colorectal tumors
por: Ludikhuize, Marlies C., et al.
Publicado: (2022)

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2011)

Mathematical modelling identifies conditions for maintaining and escaping feedback control in the intestinal epithelium
por: Fischer, Matthias M., et al.
Publicado: (2022)

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
por: Verissimo, Carla S, et al.
Publicado: (2016)

A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl(−) Transport in Ca(2+) Dynamics
por: Astaburuaga, Rosario, et al.
Publicado: (2019)

SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors
por: Liu, Ning Qing, et al.
Publicado: (2023)

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors
por: Simon, Tincy, et al.
Publicado: (2022)

Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities
por: Calandrini, Camilla, et al.
Publicado: (2022)

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype
por: Fessler, Evelyn, et al.
Publicado: (2016)

Correction to: The majority of β-catenin mutations in colorectal cancer is homozygous
por: Arnold, Alexander, et al.
Publicado: (2020)

MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments
por: Lienhard, Matthias, et al.
Publicado: (2014)

In vitro Modeling of Embryonal Tumors
por: Custers, Lars, et al.
Publicado: (2021)

Network quantification of EGFR signaling unveils potential for targeted combination therapy
por: Klinger, Bertram, et al.
Publicado: (2013)

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line
por: Genov, Nikolai, et al.
Publicado: (2019)

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
por: Mamlouk, Soulafa, et al.
Publicado: (2017)

The majority of β-catenin mutations in colorectal cancer is homozygous
por: Arnold, Alexander, et al.
Publicado: (2020)

Measuring specialization in species interaction networks
por: Blüthgen, Nico, et al.
Publicado: (2006)

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion
por: Snippert, Hugo J, et al.
Publicado: (2014)

Signaling output: it's all about timing and feedbacks
por: Blüthgen, Nils
Publicado: (2015)

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2018)

A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages
por: Klotz, Christian, et al.
Publicado: (2011)

Noise Management by Molecular Networks
por: Bruggeman, Frank J., et al.
Publicado: (2009)

SPEED2: inferring upstream pathway activity from differential gene expression
por: Rydenfelt, Mattias, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dnn6531t9akr7oevnnhmej224g