Proinflammatory plasticity towards Th17 paradigm of regulatory T cells consistent with elevated prevalence of TGFBR2 variants in elderly patients with primary immune thrombocytopenia

BACKGROUND: Primary immune thrombocytopenia (ITP) is characterized for the skewed Th differentiation towards Th1 and Th17 cells as well as the impaired number and function of regulatory T cells (Tregs). Tregs are capable of co-expressing effector Th markers in different inflammatory milieu, which pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Jingjing, Zhan, Yanxia, Ji, Lili, Chen, Pu, Cheng, Luya, Li, Feng, Zhuang, Xibing, Min, Zhihui, Sun, Lihua, Hua, Fanli, Chen, Hao, Wu, Boting, Cheng, Yunfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082480/
https://www.ncbi.nlm.nih.gov/pubmed/37029342
http://dx.doi.org/10.1186/s12865-023-00541-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082480/
https://www.ncbi.nlm.nih.gov/pubmed/37029342
http://dx.doi.org/10.1186/s12865-023-00541-8

Ejemplares similares