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Proinflammatory plasticity towards Th17 paradigm of regulatory T cells consistent with elevated prevalence of TGFBR2 variants in elderly patients with primary immune thrombocytopenia

BACKGROUND: Primary immune thrombocytopenia (ITP) is characterized for the skewed Th differentiation towards Th1 and Th17 cells as well as the impaired number and function of regulatory T cells (Tregs). Tregs are capable of co-expressing effector Th markers in different inflammatory milieu, which pr...

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Detalles Bibliográficos
Autores principales:	Cao, Jingjing, Zhan, Yanxia, Ji, Lili, Chen, Pu, Cheng, Luya, Li, Feng, Zhuang, Xibing, Min, Zhihui, Sun, Lihua, Hua, Fanli, Chen, Hao, Wu, Boting, Cheng, Yunfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082480/ https://www.ncbi.nlm.nih.gov/pubmed/37029342 http://dx.doi.org/10.1186/s12865-023-00541-8

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