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Co-profiling reveals distinct patterns of genomic chromatin accessibility and gene expression in pulmonary hypertension caused by chronic hypoxia

INTRODUCTION: Aberrant gene expression is a key mechanism underlying pulmonary hypertension (PH) development. The alterations of genomic chromatin accessibility and their relationship with the aberrant gene expressions in PH are poorly understood. We used bulk Assay for Transposase-Accessible Chroma...

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Detalles Bibliográficos
Autores principales: Yu, Dongdong, Zhang, Ting, Zhou, Guangyuan, Wu, Zeang, Xiao, Rui, Zhang, Han, Liu, Bingxun, Li, Xiangpan, Ruiz, Matthieu, Dupuis, Jocelyn, Zhu, Liping, Hu, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082509/
https://www.ncbi.nlm.nih.gov/pubmed/37031175
http://dx.doi.org/10.1186/s12931-023-02389-3