The WNK1–ERK5 route plays a pathophysiological role in ovarian cancer and limits therapeutic efficacy of trametinib

BACKGROUND: The dismal prognosis of advanced ovarian cancer calls for the development of novel therapies to improve disease outcome. In this regard, we set out to discover new molecular entities and to assess the preclinical effectiveness of their targeting. METHODS: Cell lines, mice and human ovari...

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Detalles Bibliográficos
Autores principales: Sánchez‐Fdez, Adrián, Matilla‐Almazán, Sofía, Montero, Juan Carlos, Del Carmen, Sofía, Abad, Mar, García‐Alonso, Sara, Bhattacharya, Somshuvra, Calar, Kristin, de la Puente, Pilar, Ocaña, Alberto, Pandiella, Atanasio, Esparís‐Ogando, Azucena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082568/
https://www.ncbi.nlm.nih.gov/pubmed/37029785
http://dx.doi.org/10.1002/ctm2.1217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082568/
https://www.ncbi.nlm.nih.gov/pubmed/37029785
http://dx.doi.org/10.1002/ctm2.1217

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