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Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2
The angiotensin-converting enzyme 2 (ACE2) is a viral receptor used by sarbecoviruses to infect cells. Fusion proteins comprising extracellular ACE2 domains and the Fc part of immunoglobulins exhibit high virus neutralization efficiency, but the structure and stability of these molecules are poorly...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082628/ https://www.ncbi.nlm.nih.gov/pubmed/37031320 http://dx.doi.org/10.1038/s42003-023-04762-w |